The Yale OCD Research Clinic, based at the Connecticut Mental Health Center (CMHC) in New Haven, is currently running a range of studies, running the gamut from cognitive testing to neuroimaging to pharmacological and non-pharmacological treatment studies.

They are currently conducting a new treatment study for adults with refractory OCD. They have been studying the FDA-approved drug riluzole for refractory OCD for over a decade and are now partnering with a local pharmaceutical startup, BioHaven (led by Yale’s own Vlad Coric), to test the efficacy of a riluzole prodrug (trigriluzole) that has better pharmacokinetics and tolerability than riluzole itself.

Patients for this study must have a diagnosis of OCD that is their primary psychiatric problem and must be stably medicated on an SSRI or clomipramine. Certain other antidepressants are permitted, as is stable (but not new) therapy and low-dose benzodiazepine use. The study consists of a placebo-controlled, blinded 12-week treatment phase, followed by an optional 48-week open-label continuation phase.

There are several features of this study that may make it more attractive to patients than a typical industry-sponsored drug study. First, trigriluzole is converted into riluzole in the body, and we know a great deal about riluzole’s tolerability. We also believe, based on our published research, that riluzole helps some individuals with refractory OCD. So the new drug, trigriluzole, is much less of an unknown than many novel drugs in pharmaceutical studies. Second, because of the open-label follow-up phase, everyone who enters the study has an opportunity to try the new drug. Third, since the drug’s mechanism is the same as that of riluzole, patients who get some clinical benefit during the trial can continue treatment (with rilzuole) without interruption, even if there is a delay in getting the new drug approved by the FDA.

Interested patients who would like to participate in this exciting trial can contact Christopher Pittenger, MD, PhD, director of the Yale OCD Research Clinic, by email at christopher.pittenger@yale.edu.

It’s sometimes said that Spring is a time for new beginnings, and to celebrate the IOCDF is incredibly excited to share that they are bringing back its Spotlight: OCD News & Research Updates!

Spotlight is the IOCDF’s monthly series that brings the absolute latest in OCD news and research right to your email inbox. There they feature compelling stories from advocates and cutting-edge research from the scientific community. In Spotlight, they put a special focus on the important work of its Scientific and Clinical Advisory Board experts, as well as the research and discoveries made possible through its Research Grant Program. They’re excited to be back, and look forward to sharing Spotlight with you each month!

If you would like to sign up, please click here to make sure that each month’s update arrives right in your inbox.

Excoriation (Skin Picking) Disorder is an obsessive-compulsive spectrum condition in which sufferers repeatedly pick at their skin. Crystal Quater, MMFT, of the OCD Center of Los Angeles discusses her personal experience with, and recovery from, Excoriation Disorder, and how she treats clients struggling with this condition. Click here to read the article.

In families with religious beliefs, a child expressing faith and strong moral principles is usually a welcome development. But sometimes a child’s faith may become an obsession, and instead of consolation the child experiences extreme anxiety that he is violating religious norms and desperation to correct his perceived mistakes. This is what happens when children develop obsessive-compulsive disorder and it manifests itself in their religion. Click here to read the article.

When your brain is the problem how do you fix it? Thousands of kids, teens and adults with OCD are searching for answers to this question. They’re trapped in a vicious cycle of worries and rituals. While families and loved ones are desperate to help them, fighting OCD takes time and specialized therapy.

To uncover what OCD is, and what it isn’t, filmmakers Kelly Anderson and Chris Baier focus on an unlikely group of experts: Kids!

UNSTUCK documents OCD strictly through the eyes of young people. The short documentary avoids sensationalizing compulsions and obsessions, and instead reveals the complexity of a disorder that affects the brain and behavior. As these six resilient kids and teens roadmap their process of recovery, the film inspires viewers to believe it is possible to fight their worst fears and beat back OCD.

For more information, visit www.ocdkidsmovie.com.

We understand that for people living with OCD, family members, and professionals who treat OCD and related disorders, it can sometimes be a challenge to find comprehensive information that addresses your specific needs. In addition, with all of the information out there, it can be difficult to know what sources are vetted and trustworthy.

The International OCD Foundation (IOCDF) understands these challenges. That is why it collaborates with leading experts to bring you informative and accurate information about the latest therapy, research, and treatment in OCD and related disorders. In 2018, it is its goal to ensure that more of this information is available to you on its website. That’s why it has recently revamped its “Expert Opinions” section to now be called “From the Experts”, and include even more relevant and informative articles.

Its “From the Experts” section includes articles that are relevant and accessible to people living with OCD and their loved ones, as well as to mental health professionals. Its articles go beyond what it covers in its “Learn More About OCD” sections, in order to provide more in-depth looks at various areas of OCD management and treatment. Click here to view the articles.

The OCD Center of Los Angeles is happy to announce the publication of a new article by one of its staff therapists, Lauren McMeikan, MA. The article, titled Body Image: Don’t Believe Everything You Think, explores how you can use mindfulness and acceptance to challenge the negative, self-defeating messages you tell yourself about your body. Click here to read the article.

Are you interested in trying to control your own brain patterns while participating in cutting-edge research? Using functional magnetic resonance imaging (fMRI) to produce real-time reports of brain activity, this Yale research study for adults can help train you to regulate an area of your brain relevant to OCD while also offering compensation of up to $460! For more information on this study, please visit http://ocd.yale.edu/patients/treatment.aspx or contact us by email at OCDnfResearch@yale.edu; by phone at (203) 737-6055.

Even though I’m not obsessed with monsters under the bed anymore, when something unpleasant comes up, like getting called in for jury duty, my mind automatically brings me to the irrational worst case. There are 7 things I wish people understood about OCD. Click here to read this article.

By now, virtually anyone with even a passing interest in politics and current events has heard the term “fake news”. If you haven’t heard this term, just turn on a cable news channel on any given day and you are bound to hear a news story (or ten) about how we are being inundated with fake news that is designed to alter our political beliefs (and our votes). Regardless of your political persuasion, a Google search of the term “fake news” will lead you to a multitude of articles that describe somebody (or some country) that is presenting reality in a distorted fashion in an attempt to persuade you to see things their way. So what does this have to with OCD? Click here to read an article that will explain.